Administered paricalcitol dose and survival in hemodialysis patients: A marginal structural model analysis
نویسندگان
چکیده
منابع مشابه
Dose of hemodialysis and survival: a marginal structural model analysis.
BACKGROUND Observational studies have consistently demonstrated the survival benefits of a greater dialysis dose in maintenance hemodialysis (MHD) patients, whereas randomized controlled trials have shown conflicting results. The possible causal impact of dialysis dose on mortality needs to be investigated using rich cohort data analyzed with novel statistical methods such as marginal structura...
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It has been previously reported that a higher erythropoiesis stimulating agent (ESA) dose in hemodialysis patients is associated with adverse outcomes including mortality; however the causal relationship between ESA and mortality is still hotly debated. We hypothesize ESA dose indeed exhibits a direct linear relationship with mortality in models of association implementing the use of a marginal...
متن کاملComparing mortality in renal patients on hemodialysis versus peritoneal dialysis using a marginal structural model.
When comparing the causal effect of peritoneal dialysis (PD) and hemodialysis (HD) treatment on lowering mortality in renal patients, using observational data, it is necessary to adjust for different forms of confounding and informative censoring. Both the type of dialysis treatment that is started with and mortality are affected by baseline covariates. Longitudinal and baseline variables can a...
متن کاملComparing mortality of peritoneal and hemodialysis patients in the first 2 years of dialysis therapy: a marginal structural model analysis.
BACKGROUND AND OBJECTIVES There are conflicting research results about the survival differences between hemodialysis and peritoneal dialysis, especially during the first 2 years of dialysis treatment. Given the challenges of conducting randomized trials, differential rates of modality switch and transplantation, and time-varying confounding in cohort data during the first years of dialysis trea...
متن کاملRatio of paricalcitol dosage to serum parathyroid hormone level and survival in maintenance hemodialysis patients.
BACKGROUND AND OBJECTIVES Several observational studies have indicated that vitamin D receptor activators (VDRA), including paricalcitol, are associated with greater survival in maintenance hemodialysis (MHD) patients; however, patients with higher serum parathyroid hormone (PTH), indicative of a more severe secondary hyperparathyroidism and higher death risk, are usually given higher VDRA dosa...
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ژورنال
عنوان ژورنال: Pharmacoepidemiology and Drug Safety
سال: 2012
ISSN: 1053-8569
DOI: 10.1002/pds.3349